Primary urethral carcinoma is a rare disease globally and is much less commonly in African (< 20%).The knowledge of proper management for urethral cancer is limited due to lower prevalence of the disease. Furthermore, the consequences of the management of urethral carcinoma remains a challenge to both clinician and patients as it may results in removal of sexual organs and ending in long term catheters. Here we present case series of both 1 male and 2 females with challenges in the management from a tertiary hospital in Northern Tanzania.