Direct detection of heteroresistance in Mycobacterium tuberculosis using molecular techniques (Correspondence)

Cullen,M.M.; Sam,N.E.; Kanduma,E.G.; McHugh,T.D.; Gillespie,S.H. J Med Microbiol 55 (2006), 1157-1158
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The risk of resistance emerging during the treatment of tuberculosis (TB) is ever present. The simultaneous detection of both ethambutol-sensitive and -resistant genotypes in sputum specimens predicted or known to have drug-resistant TB has been reported, a phenomenon described as heteroresistance. We extend this observation by detecting pre-existing mutants in the sputum of patients from a population in Tanzania in which resistance is unlikely.