Several neuropsychiatric manifestations have been documented among patients with systemic lupus erythematosus (SLE). However, considerable challenges exist in diagnosing and management of neuropsychiatric symptoms especially in resource constrained settings. More literature in this setting is needed to further inform clinicians of their existence, diagnosis and challenges faced. We report a case of a 30 years old female who was referred to us as a case of anemia three days post caesarean section with evolving symptomatology including severe endometritis and neuropsychiatric symptoms. Delayed diagnosis of SLE led to a more prolonged hospital stay. However, multidisciplinary team approach saved the day by reaching the correct diagnosis for the underlying complex symptoms resulting into appropriate management